2004•Unpublished venueRequires access

Effects of Estrogen on Liver Ischemia Reperfusion Injury in Rats

Lei Zhang

Abstract

Objective: To study the mechanism and the effect of estrogen on ischemia-reperfusion(I/R) injury in male rat liver. Methods: Sixty SD male rats were randomly divided into 3 group, A: shame operation group(n=20); B: ischemia-reperfusion group (n= 20);C:estrogen treatment group(n=20). Serum ALT、AST、AKP、tumour necrosis factor-α(TNF-α) and the numbers of polymorphonu-clear cells (PMNs) in liver were analysed statistically among three groups. Results: Group B had higher levels of ALT、AST、AKP and TNF-α than group C. Conclusion: Estrogen significantly protects liver from ischemia-reperfusion injury. The mechanism of protection may be related to decreased serum TNF-α.

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Key concepts: Estrogen, Ischemia, Medicine, Reperfusion injury, Internal medicine, Endocrinology, Group B, Liver injury