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2009•Medical Journal of Chinese People's HealthRequires access

A comparative study of Paroxetine combined with Olanzapine in the treatment of refractory depression

Lili Wang

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Abstract

Objective:To explore the efficacy and safety of Paroxetine combined with Olanzapine in the treatment of refractory depression. Methods:A total of 58 patients with refractory depression were randomly divided into study group with Paroxetine combined with Olanzapine and control group with Paroxetine for 8 weeks of treatment. The clinical efficacy and side effects were assessed with Hamilton Depression Scale ( HAMD ) 、 Hamilton Anxiety Scale ( HAMA ) and Treatment Emergent symptom Scale ( TESS ). Results : After treatment, the scores of HAMD and HAMA in two groups were both significantly lower than those before treatment, In the 2nd 、 4th 、6th、and 8th weekend of treatment, the scores of HAMD and HAMA in study group were significantly lower than those in control group. No severe side effects were found in two groups. Conclusions: Paroxetine augmented with Olanzapine takes effects better and faster than Paroxetine single and doesnt increase side effects in the treatment of refractory depression.

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Objective:To explore the efficacy and safety of Paroxetine combined with Olanzapine in the treatment of refractory depression. Methods:A total of 58 patients with refractory depression were randomly divided into study group with Paroxetine combined with Olanzapine and control group with Paroxetine for 8 weeks of treatment. The clinical efficacy and side effects were assessed with Hamilton Depression Scale ( HAMD ) 、 Hamilton Anxiety Scale ( HAMA ) and Treatment Emergent symptom Scale ( TESS ). Results : After treatment, the scores of HAMD and HAMA in two groups were both significantly lower than those before treatment, In the 2nd 、 4th 、6th、and 8th weekend of treatment, the scores of HAMD and HAMA in study group were significantly lower than those in control group. No severe side effects were found in two groups. Conclusions: Paroxetine augmented with Olanzapine takes effects better and faster than Paroxetine single and doesnt increase side effects in the treatment of refractory depression.

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Available abstract

Objective:To explore the efficacy and safety of Paroxetine combined with Olanzapine in the treatment of refractory depression. Methods:A total of 58 patients with refractory depression were randomly divided into study group with Paroxetine combined with Olanzapine and control group with Paroxetine for 8 weeks of treatment. The clinical efficacy and side effects were assessed with Hamilton Depression Scale ( HAMD ) 、 Hamilton Anxiety Scale ( HAMA ) and Treatment Emergent symptom Scale ( TESS ). Results : After treatment, the scores of HAMD and HAMA in two groups were both significantly lower than those before treatment, In the 2nd 、 4th 、6th、and 8th weekend of treatment, the scores of HAMD and HAMA in study group were significantly lower than those in control group. No severe side effects were found in two groups. Conclusions: Paroxetine augmented with Olanzapine takes effects better and faster than Paroxetine single and doesnt increase side effects in the treatment of refractory depression.

Key concepts: Paroxetine, Hamd, Olanzapine, Depression (economics), Hamilton depression scale, Refractory (planetary science), Medicine, Psychology

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