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2004•Zhejiang Medical JournalRequires access

The effect of simvastatin on C reactive protein in patients with coronary heart disease

Wenbiao Wang

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Abstract

Objective To investigate the changes of C reactive protein (CRP) in coronary heart disease (CHD) and the effect of simvastatin on CRP. Methods The plasma CRP levels were evaluated in patients with CHD and age-matched normal control group. Patients with CHD were randomized to simvastatin group and non-simvastatin group, and the CRP levels were measured before and after treatment. Results The plasma CRP levels in patients with CHD were significantly higher than those of normal controls (9.87±2.32)mg/ml vs (4.28±1.23)mg/ml(P0.01) . In simvastatin group the plasma CRP levels were significantly decreased after treatment (7.31±2.87)mg/ml, while those of non-simvastatin group remained higher level (9.22±2.54)mg/ml. The latter was significantly higher than former (t=2.34, P0.05). Conclusion Patients with CHD have significantly higher plasma CRP. Simvastatin can decrease the CRP level in patients with CHD.

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What this paper is about

Objective To investigate the changes of C reactive protein (CRP) in coronary heart disease (CHD) and the effect of simvastatin on CRP. Methods The plasma CRP levels were evaluated in patients with CHD and age-matched normal control group. Patients with CHD were randomized to simvastatin group and non-simvastatin group, and the CRP levels were measured before and after treatment. Results The plasma CRP levels in patients with CHD were significantly higher than those of normal controls (9.87±2.32)mg/ml vs (4.28±1.23)mg/ml(P0.01) . In simvastatin group the plasma CRP levels were significantly decreased after treatment (7.31±2.87)mg/ml, while those of non-simvastatin group remained higher level (9.22±2.54)mg/ml. The latter was significantly higher than former (t=2.34, P0.05). Conclusion Patients with CHD have significantly higher plasma CRP. Simvastatin can decrease the CRP level in patients with CHD.

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Available abstract

Objective To investigate the changes of C reactive protein (CRP) in coronary heart disease (CHD) and the effect of simvastatin on CRP. Methods The plasma CRP levels were evaluated in patients with CHD and age-matched normal control group. Patients with CHD were randomized to simvastatin group and non-simvastatin group, and the CRP levels were measured before and after treatment. Results The plasma CRP levels in patients with CHD were significantly higher than those of normal controls (9.87±2.32)mg/ml vs (4.28±1.23)mg/ml(P0.01) . In simvastatin group the plasma CRP levels were significantly decreased after treatment (7.31±2.87)mg/ml, while those of non-simvastatin group remained higher level (9.22±2.54)mg/ml. The latter was significantly higher than former (t=2.34, P0.05). Conclusion Patients with CHD have significantly higher plasma CRP. Simvastatin can decrease the CRP level in patients with CHD.

Key concepts: Simvastatin, Medicine, Coronary heart disease, C-reactive protein, Internal medicine, Plasma levels, Gastroenterology, Cardiology

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