2013•Hebei yiyaoRequires access
Expression and clinical significance of Notch-1 and Survivin in papillary thyroid carcinoma
Shi Yonglian
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Abstract
Objective To explore the expression and clinical significance of Notch-1 and Survivin in papillary thyroid carcinoma tissues.Methods The expression levels of Notch-1 and Survivin were detected by immunohistochemistry in 80 cases of papillary thyroid carcinoma,70 cases of thyroid adenoma and 50 cases of normal thyroid gland tissues.The correlation between the expression levels and clinical pathological parameters was analyzed.Results The positive expression rate of Notch-1 in papillary thyroid carcinoma,thyroid adenoma and normal thyroid gland tissues was 22.5%,78.6%,88.0%,respectively,and the positive expression rate of Survivin was 70.0%,12.9%,0%,respectively,in papillary thyroid carcinoma,thyroid adenoma and normal thyroid gland tissues.As compared with that in thyroid adenoma and normal thyroid gland tissues,Notch-1 in papillary thyroid carcinoma was low-expressed,however,Survivin was over-expressed (P0.05),furthermore the expression of Notch-1 was closely correlated to that of Survivin (P0.01).The abnormal expression of Notch-1 and Survivin in papillary thyroid carcinoma was related to clinical stage and lymph node metastasis of the tumor (P0.05).Conclusion The abnormal expressions of Notch-1 and Survivin exist during invasion and metastasis of papillary thyroid carcinoma,and combined detection of the two markers is helpful to evaluating the prognosis and outcome of papillary thyroid carcinoma.