Variation and significance of pathological diagnosis during treatment of high-grade cervical intraepithelial neoplasia with loop electrosurgical excision

Objective To investigate the variations of pathological diagnosis during diagnosis and treatment of high-grade cervical intraepithelial neoplasia(CIN) with loop electrosurgical excision procedure(LEEP).Methods Fifty-seven patients received cervical conization by LEEP with histopathological diagnosis of CIN Ⅲ,Ⅰa and Ⅰb 1.The results of liquid-based thinprep cytological test before treatment and histopathologic examination by colposcopical biopsy,LEEP and hysterectomy were analyzed.Results Of 46 cases of CIN Ⅲ,8 cases was ASC-US.Of 9 cases of Ⅰa 1,one case was ASC-US.The consistent rate of pathlolgical diagnosis with biopsy of LEEP was 54.4%(3157) in 57 CIN cases.Fourty-four cases of CIN Ⅲ diagnosed by the LEEP underwent hysterectomy,of whom 24 cases presented CIN in the uterus with the same pathological diagnosis as that of LEEP.The residual rate of positive margin after LEEP was 75.0%(2128).Conclusion A reasonable management of ASC-US is helpful for avoiding missed diagnosis of serious pathological changes.Colposcopically directed biopsy has a certain limitation.LEEP is a kind of effective method in the diagnosis and treatment of CIN and all the patients should be followed up whether the diagnosis of incision margin is positive or negative.