Detection of biliary bacteria and analysis of drug resistance to antibiotics

Objective To investigate the species of the main pathogenic bacteria of biliary infection and their resistance rates to the commonly used antibiotics so as to instruct rational application of antibiotics clinically. Methods The data of 73 strains of aerobes found in 69 inpatients with positive bile culture from Jan 1998 to Jun 2002 and their sensitivity to antibiotics were statistically analyzed. Results The cultured positive rate in the specimens was 70.4%(69/98). Among the isolates,most of the pathogenic bacteria were Escherichia coli,Klebsiella pneumoniae and intestinal cocci. Imipenem,amikacin and ceftazidime are the relatively active against the gram negative bacillus,and all the gram positive cocci were sensitive to vancomycin. Conclusion The main pathogenicmicrobes of biliary infection were Escherichia coli,Klebsiella pneumoniae and intestinal cocci.In clinical therapy, sensitivity to antibiotics should selected based on the drug sensitive test,combined with other agents when necessary.