Study on 304 strains of pathogenic bacteria causing biliary tract infection and their sensitivity to antibiotics

OBJECTIVE To study the changing tendency of drug resistance of pathogenic bacteria in bile causing biliary tract infection.METHODS The data of 304 strains of aerobes isolated from 269 patients with positive bile culture from Jan 2006 to Dec 2009 and their sensitivity to antibiotics were analyzed.RESULTS The 304 strains of aerobes belonged to 52 species:Gram-negative bacteria accounted for 59.5% and Gram-positive coci accounted for 40.5%.The leading five bacteria detected were Escherichia coli(20.4%),Enterococcus faecalis(16.8%),Klebsiella pneumoniae(11.2%),Pseudomonas aeruginosa(8.9%) and Enterobacter cloacae(7.9%).The sensitivities of the bacteria to penicillin,cephalosporins and quinolones were generally declined.However,they were highly sensitive to imipenem,meropenem,vancomycin and teicoplanin.CONCLUSIONS Types of pathogens of biliary tract infection and their antibiotic resistance are increasing.So it is important to keep on detecting the changes of antibiotics sensitivity and rationally using the antibiotics.