Pathogenic bacteria causing biliary infection and changes of drug sensitivity to antibiotics

OBJECTIVE To study the changes of biliary bacteria and their sensitivity to antibiotics.METHODS The data of 323 strains of aerobes found in 264 patients with positive bile culture from Jan 2006 to Dec 2009 and their sensitivity to antibiotics were statistically analyzed.RESULTS The 323 strains of aerobes belonged to 52 species:Gram negative bacteria accounted for 59.4% and Gram positive cocci accounted for 40.6%.The leading six bacteria detected were Enterococcus(22.0%),Escherichia(19.5%),Klebsiella(11.8%),Staphylococcus(10.9%),Pseudomonas aeruginosa(8.7%) and Enterobacter(8.4%).Among 59 cases of mixed infection,12cases and 10 cases were infected with Escherichia and P.aeruginosa respectively.The bacteria were highly resistant to penicillin,cephalosporins and quinolones.However,they were highly sensitive to imipenem,meropenem,vancomycin and teicoplanin.The bacteria kept high sensitivity to amikacin.Especially 68.7% of P.aeruginosa were sensitive to it.CONCLUSION Types of pathogens of biliary tract infection as well as their antibiotic resistance are increasing,so it is important to keep on detecting the changes of biliary bacteria and their sensitivity to antibiotics and proper use of antibiotics.