Correlation between Ser447stop Gene Polymorphism of Lipoprotein Lipase and Stroke

Objective To study the association of lipoprotein lipase Ser447stop gene polymorphisms with cerebral infarction and cerebral hemorrhage.Methods The lipoprotein lipase Ser447stop genotypes were detected by PCR-RFLP in 227 subjects(including 87 cerebral infarction patients and 71 cerebral hemorrhage patients and 85 controls).The serum levels of lipids and apolipoproteins were detected in all the subjects.Results The C allele in control group was 81.18%,G allele 18.82%;the C allele cerebral infarction group was 93.1%,G allele 6.9%;the C allele in cerebral hemorrhage group was 93.1%,G allele 6.9%;the ratio of G allele was significantly different among the three groups(P0.05);The TG,LDL-c levels in cerebral infarction group and cerebral hemorrhage group were higher than that in the control group(P0.05);and the ApoAⅠ,ApoB100 levels in cerebral infarction group and cerebral hemorrhage group were lower than that in the control group(P0.01).Conclusion Lipoprotein lipase Ser447stop gene polymorphism is correlated with cerebral infarction,LPL Ser447stop G allele mutation is a protective factor for cerebral infarction and cerebral hemorrhage.