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2006•Guangxi Medical JournalRequires access

Relationship of lipoprotein lipase PvuII gene polymorphisms with cerebral infarction

Luo Yong-jian

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Abstract

Objective To study the association of lipoprotein lipase PvuⅡ gene polymorphisms with cerebral infarction.Methods PCR-RFLP was used to detect 148 subjects' lipoprotein lipase PvuⅡ genotypes(including 81controls;67 cerebral infarction patients).All the subjects' serum lipids and apolipoproteins levels were detected.Results (1)60.5% of the cerebral infarction group carry P+ allele,39% P-allele;63% of the control group carry P+ allele,37% P-allele(P0.05);(2)The cerebral infarction group had higher TG、CHO、LDL-c levels than the control group (P0.05);and the cerebral infarction group had lower apoAⅠ levels than the control group(P0.05).Conclusions The lipoprotein lipase PvuⅡpolymorphism is not correlated with cerebral infarction.

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Objective To study the association of lipoprotein lipase PvuⅡ gene polymorphisms with cerebral infarction.Methods PCR-RFLP was used to detect 148 subjects' lipoprotein lipase PvuⅡ genotypes(including 81controls;67 cerebral infarction patients).All the subjects' serum lipids and apolipoproteins levels were detected.Results (1)60.5% of the cerebral infarction group carry P+ allele,39% P-allele;63% of the control group carry P+ allele,37% P-allele(P0.05);(2)The cerebral infarction group had higher TG、CHO、LDL-c levels than the control group (P0.05);and the cerebral infarction group had lower apoAⅠ levels than the control group(P0.05).Conclusions The lipoprotein lipase PvuⅡpolymorphism is not correlated with cerebral infarction.

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Available abstract

Objective To study the association of lipoprotein lipase PvuⅡ gene polymorphisms with cerebral infarction.Methods PCR-RFLP was used to detect 148 subjects' lipoprotein lipase PvuⅡ genotypes(including 81controls;67 cerebral infarction patients).All the subjects' serum lipids and apolipoproteins levels were detected.Results (1)60.5% of the cerebral infarction group carry P+ allele,39% P-allele;63% of the control group carry P+ allele,37% P-allele(P0.05);(2)The cerebral infarction group had higher TG、CHO、LDL-c levels than the control group (P0.05);and the cerebral infarction group had lower apoAⅠ levels than the control group(P0.05).Conclusions The lipoprotein lipase PvuⅡpolymorphism is not correlated with cerebral infarction.

Key concepts: Cerebral infarction, Lipoprotein lipase, Internal medicine, Allele, Genotype, Endocrinology, Polymorphism (computer science), Medicine

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