2008•Unpublished venueRequires access
Relationship of Lipoprotein Lipase Ser447stop Gene Polymorphisms with Cerebral Infarction
Huiqiong Lin
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Abstract
Objective To study the association of lipoprotein lipase Ser447stop gene polymorphisms with cerebral infarction.Methods Use a PCR-RFLP to detect 125 subjects'lipoprotein lipase Ser447stop genotypes(including 62 controls;63 cerebral infarction patients).Detected all the subjects'serum lipids and apolipoproteins levels.Results ①The cerebral infarction group carry C allele 91.27%,G allele 8.73%;the control group carry C allele 80.65%,G allele 19.35%;the ratio of G allele was significantly different among the cerebral infarction group and the control group(P0.05).②The cerebral infarction group had higher TG,LDL-c levels than the control group(P0.05);and the cerebral infarction group had lower CHO,ApoAⅠ,ApoB100 levels than the control group(P0.05).Conclusion The lipoprotein lipase Ser447stop gene polymorphism is correlated with cerebral infarction,and the G allele may be a protective factor against cerebral infarction.