Pharmacokinetics and Bioavailability of Sarafloxacin Hydrochloride in Chickens

The pharmacokinetics and bioavailability of sarafloxacin hydrochloride,following intravenous and oral administration of single dose 10 mg sarafloxacin/kg,were determined in 8 healthy chickens weighing 1.66±0.11) kg(mean±s),respectively.The serum concentration of sarafloxacin was measured by HPLC method.Pharmacokinetic parameters were obtained by computer calculation.The results showed that:the serum concentration-time date of sarafloxacin were fitted with a two-compartment model for intravenous administration.The elimination hafe-life(t 1/2β),the total body clearance(CL B),the volume of distribution(V d) and the area under the curve(AUC),were 2.678±0.506 h,1.339±0.351 L/kg·h,5.159±1.554 L/kg and 7.853±1.731 mg/L·h,respectively.Following oral administration,the drug concentration-time best described by a one-compartment absorption open model,the absorption and elimination half-lives (t 1/2ka?t 1/ke),the peak serum concentration (C max) and the time to reach C max(T max) were 0.287±0.117 h,5.381±1.446 h,0.478±0.196 mg/L ,1.229±0.439 h and 4.060±1.178 mg/L·h,respectively.The bioavailability(F) ranged from 31.83 to 69.90 (51.70±15.00%)?