Pharmacokinetic Studies of Sarafloxacin in Chickens

Pharmacokinetics of Sarafloxacin were investigated in 30 healthy Avine broiler chickens following single intravenous,intramuscular and oral administration at the dosage of 10 mg/kg b.w. of the drug.Blood samples were collected at different intervals after administration and sarafloxacin concentrations were determined by HPLC method with a fluorescent detector.The sarafloxacin concentration time data were fitted to a two compartment open model after single i.v. dosing in healthy chickens.The main pharmacokinetic parameters were as follows:t 1/2α (0 19±0 09) h;t 1/2β (1 94±0 70) h;V 1(1 22±0 67) L/kg;V d(area) (3 89±1 58) L/kg;Cl B(1 30±0 19) L·kg -1 ·h -1 ;AUC(7 89±1 50) mg·L -1 ·h -1 .The drug concentration time data were fitted to a two compartment model with first order absorption after single i.m. dosing in healthy chickens.The main pharmacokinetic parameters were as follows:t 1/2ka (0 22±0 19) h;t 1/2α (0 95±0 93) h;t 1/2β (5 19±2 04) h;t max (0 65±0 35) h;C max (1 20±0 30) mg/L;AUC(5 66±1 15) mg·L -1 ·h -1 ;F(71 67±14 59)%。After single p.o. administration in healthy chickens.The drug concentration time data were analyzed by statistical moment methods.The main pharmacokinetic parameters were as follows:t 1/2β (3 89±1 19) h;t max (1 18±0 73) h;C max (0 86±0 31) mg/L;AUC(5 12±1 19) mg·L -1 ·h -1 ;F(59 63±13 8)%;MAT(2 87±1 11) h;MRT(5 70±1 11) h.The results showed that Sarafloxacin was absorbed fast and distributed extensively in chickens.The absorption of the drug was uncomplete after single i.m. and p.o. administration and eliminated slowly after i.m. administration in healthy chickens.