Studies on pharmcokinetics and residues of Sarafloxacin Hydrochloride in chickens

chickens were selected to study pharmacokinetics and residues of Sarafloxacin Hydrochloride.Pharmacokinetics showed that the blood concentration time course could be described with the first compartment open model with the first order absorption after oral administration(10 mg/kg).It's main pharmacokinetics parameters were Ka 1.6025 h -1 、t max 1.5807 hrs、c max 0.7429 μg/ml、AUC5.3790 μg/ml.h.The heart and kidney concentration time date of Sarafloxacin Hydrochloride were best described by a triexponential equation with the first order absorption.Their main pharmacokinetics paramters were t 1/2B 7.765hrs、40.26hrs,t 1/2α 1.6027hrs、4.418hrs、t max 1.6826hrs、1.9855hrs、c max 0.5129 μg/ml、0.9090 μg/ml,AUC9.0265、10.894 μg/ml.h.The liver and muscle concentration time data of Sarafloxacin Hydrochloride were best described by a biexponential equation with first order absorption.Their main pharmacokinetics parameters were t 1/2k 3.1587hrs、4.124hrs,t max 1.9764hrs、3.5679hrs,c max 3.737 μg/ml、0.6956 μg/ml,AUC31.354 μg/ml.h、5.3269 μg/ml.h.The residues of Sarafloxacin Hydrochloride in chickens were 7 days.