Pharmacokinetic Studies of Sarafloxacin in Pigs

Pharmacolinetics of sarafloxaxin were investigated in 7 healthy cross bred pigs following a single intravenous,intramuscular and oral administration of the drug at the dose of 5 mg/kg b.w.Blood samples were collected at different intervals after administration and sarafloxacin concentrations were determined by HPLC method with a limit of detection of 0 05 μg/ml.The sarafloxacin concentration time data were fitted to a two compartment open model after single i.v. dosing in healthy pigs.The main pharmacokinetic parameters were as follows:t 1/2α 0 88±0 28 h;t 1/2β 3 06±0 50 h;V 11 36±0 24 L/kg;V d(area) 2 50±0 42 L/kg;Cl B 0 57±0 07 L·kg -1 ·h -1 ;AUC 8 90±1 03 mg·L -1 ·h.The drug concentration time data were fitted to a one compartment model with first order absorption after single i.m.dosing in healthy pigs.The main pharmacokinetic parameters were as follows:t 1/2ka 0 25±0 18 h;t 1/2ke 3 53±1 01 h;t max 0 94±0 49 h;C max 1 30±0 37 μg/ml;AUC 7 66±1 38 mg·L -1 ·h;F86 48%±15 15%.The drug concentration time data were fitted to a one compartment model with first order absorption after single p.o.administration in healthy pigs.The mainpharmacokinetic parameters were as follows:t 1/2ka 0 51±0 29 h;t 1/2ke 6 72±2 78 h;t max 2 45±0 89 h;C max 0 36±0 21 μg/ml;AUC 4 54±1 06 mg·L -1 ·h;F51 99%±14 67%.The results of present studies showed that sarafloxacin was absorbed fast and distributed extensively in pigs.The drug was completely absorbed after a single i.m.administration and slowly eliminated after p.o.administration in healthy pigs.