Expression of CK20 and PCNA in Gastric Carcinoma and Its Clinical Significance

Objective: To study the expression of CK20 and PCNA in gastric carcinoma to discuss its clinical significance.Methods: The expression of CK20 and PCNA in the tumor tissues from 30 patients with gastric carcinoma was examined immunohistochemistrically by the SP method.(Results:) The expression of CK20 in gastric carcinoma was related with the differentiation,clinical pathologic stage,lymph metastasis and depth of invasion(P0.05).The clinical pathologic stage,the differentiation of adenocarcinoma and lymph metastasis were correlated with the positive rate of PCNA expression(all P0.05).A positive correlation was noted between expression of CK20 and PCNA(r=0.472,P=0.007).Neither the expression of CK20 nor PCNA in gastric carcinoma was correlated with sex,age and histological type(all P0.05).Conclusion: Combining detection of CK20 and PCNA expression can offer a valuable reference to evaluate the metastasis and prognosis in gastric carcinoma.