Expression of VEGF,COX-2 and HIF-1α and their significance in endometrial carcinoma

Tissues from 46 EMC patients,22 cases with atypical hyperplasia of endometrium and 19 cases with normal human endometrium as control were examined immunohistochemically for the VEGF,COX-2 and HIF-1αproteins.The results showed that the expression levels of VEGF,COX-2 and HIF-1αincreased in EMC,and they increased with the increase of tumor grade and FIGO stage,which showed the promotive function of the three factors during the process of endometrial pathological changes.COX-2 and HIF-1αmight regulate upon VEGF respectively in endometrium,and both might become the targets in anti-vessel therapy of endometrial neoplasms.