Clinical study on the efficacy of phentolamine、magnesium sulfate and famotidine in treatment of 63 severe asthma patients

Objective To observe the effect of phentolamine,magnesium sulfate combined with famotidine injection on severe asthma.Methods 87 cases with severe asthma during acute seizure phase were randomly divided into two groups.The control group(n=24)was treated with conventional therapy of western medicine.Intervention group(n=63)were treated with phentolamine injection 10mg,magnesium sulfate injection 2.5g、famotidine injection 40mg infused intravenously except for the conventional therapy of western medicine which used for the control group.The curative efficacy and the variations of vital capacity(VC),forced vital capacity(FVC),and forced expiratory volume(FEV1)were observed before and after the therapy.Results The total effective rates in two groups were 96.8% and 79.2%,respectively.The curative efficacy in intervention group was significantly superior to that in control group(P0.01).After therapy the pulmonary functions were significantly improved in the intervention group.The VC before and after treatment were(1.79±0.39)L and(2.51 ±0.65)L(P﹤0.01),respectively,for FVC were(1.91±0.51)L and(2.41±0.66)L(P﹤0.01),respectively,for FEV1 were(0.93±0.75)L and(1.42 ±0.39)L(P﹤0.01),respectively.Compared with the control group,they were significantly different(P 0.01).Conclusion In the base of conventional therapy,combined with phentolamine,magnesium sulfate and famotidine injection can improve the treatment of severe bronchial asthma.