The influence of magnesium sulfate as an adjunctive treatment on lung function of children with severe asthma

Objective: To investigate the influence of magnesium sulfate as an adjunctive treatment on the lung function of children with severe asthma.Methods: Forty children with severe asthmatic status were randomly divided into 2 groups(n=20).The routine group was mainly subjected to β2 receptor agitator(albuterol) inhalation,glucocorticoid and aminophylline intravenously as control;Mg group were treated with 25 mg/kg MgSO4 intravenously and 60 mg/mL MgSO4 inhalation,based on routine therapy.Their therapeutic effectiveness was observed including hospital staying,drug side-effects,their lung function,serum magnesium and urinal magnesium levels before and after 3 d treatment.Results: The duration of asthma remission and hospital in routine group were longer than that of Mg group(P0.05).The total effective rate in Mg group was higher than that of control(P0.05).after 3 d.The side-effects of magnesium sulfate were mild,and there was no statistical difference between two groups.Compared with their lung function before therapy,the forced vital capacity(FVC),1s forced expiratory volume(FEV1) and peek expiratory flow rate(PEFR) in two groups improved;but the level of lung function in Mg group was significantly dominant than the routine group(P0.05).The serum magnesium had no change in two groups before and after 3 d treatment.The ratio of urine magnesium to creatinine in Mg group was higher than that of the routine group after 3 d treatment(P0.05).Conclusion: Magnesium sulfate as an adjunctive therapy for children with severeasthma is effective and safe,and improves their lung function obviously.