A Clinical Study on NO Level and Change Rule of Serum in Patients with Virus Hepatitis and Cirrhosis

Objective To study the change rule of serum NO level in patients with virus hepatitis and cirrhosis.Methods Serum NO was detected in 152 cases of virus hepatitis and cirrhosis, its regular change was analyzed and was compared with the different disease course, serum albumin, hepatic fibrosis mark and Child-Pugh.Results (1) Serum concentration of NO was significantly different in virus hepatitis and cirrhosis group from that of the control group. (2) Serum concentration of NO was higher in the active phase of illness, it was less after the convalescent period of illness (P0.01). (3) Serum concentration of NO was higher than normal range group of serum albumin on lower range group of serum albumin (t=9.41,P0.01). (4) Serum concentration of NO was the highest in the C group of the Child-Pugh.(5)Serum concentration of NO on ascites group of cirrhosis was higher than non-ascites group (t=10.82,P0.01). (6) Among the patients with the raised HA, LN, IV-C and PCⅢ, serum concentration of NO was higher.Conclusion Serum concentration change of NO was relative with hepatic inflammation, severe degree of hepatitis and clinical development in virus hepatitis and cirrhosis.