Clinical Significance of Serum Nitric Oxide Change in Patients with Chronic Hepatitis B and Liver Cirrhosis

Objective: To study the clinical significance of the serum nitric oxide(NO) level changes in patients with chronic hepatitis B and liver cirrhosis.Methods:The serum NO level was detected in 60 patients with chronic hepatitis B,20 patients with liver cirrhosis and 30 healthy donors by nitrate reductase method.Results:The patients with chronic hepatitis B showed higher serum NO level than healthy control group(P0.001),The serum NO level was higher in patients with liver cirrhosis than that in patients with chronic hepatitis B(P0.001).The higher Child-pugh,the higher serum NO level.The serum NO level was higher in the B group of the Child-pugh than that in the A group(P0.05).The serum NO level was higher in the C group of the Child-pugh than that in the B group(P0.01).Conlusions:The serum NO level in the patients with disease could reflect the damage to liver function and the severe degree of liver cirrhosis.The serum NO level may also act as one of indictators to evaluate therapeutic efficacy of liver disease treatment.We could find a new way and theoretical basis for treating liver disease through the study of NO.