Hemodynamic Effects of Propofol and Fentanyl on Critically Ill Patients for Long term Sedation During Mechanical Ventilation

Objective:This article was to investigate the hemodynamic effects of the mixture from propofol and fentanyl on propofol critically ill patients for prolonged sedation during mechanical ventilation.Methods: 24 patients were admitted to ICU with mechanical ventilation and sedation started as required. Eleven patients were assigned to placebo group receiving midazolam 5 10 mg or fentanyl 0.1 0.2 mg i.v;and thirteen to propofol group recieving infusion of a mixture from propofol 400 mg and fentanyl 0.5 mg at 2 ml·kg -1 ·h -1 for a maximum of 4 days. Results:CI and SI increased significantly in propofol group on the second day of adminision to ICU ( P 0.01). MAP and PAP decreased lightly,but the differences were not significant. HR,CVP and PCWP were found to have no changes in either group. Propofol significantly decreased SVRI and PVRI on the second day of adminision ( P 0. 05).Conclusion:Infusion of mixed liquid for propofol and fentanyl could provide satisfactory sedation for ICU patients with little hemodynamic changes.