Hemodynamic Effects of Propofol and Fentanyl on Aged Patients During Mechanical Ventilation

Objective The aim of study is to evaluat the effects of the hemodynamic effects of the propofol combined fentanyl on elder patients during mechanical ventilation. Methods Thirty aged patients which were admitted to ICU with mechanical ventilation were randomly divided into two group, P + F group (n = 15) receiving propofol + fentanyl infusion, propofol group(n = 15) receiving only receiving infusion. Then record the MAP、HR、CI、SI、ACI、SVRI before using and 12、24、48 hours after sedation. Results CI、SI and ACI de-creased significantly in propofol group on 12 hours after sedation(P<0.05). The SVRI of P + F group de-creased significantly on the same time (P<0.05). The total volume of using propofol in P + F group was less than the propofol group (P<0.05). Conclusion Compare using propofol alone, propofol combined fentanyl could provide satisfactory sedation for aged patients during mechanical ventilation with little hemodynarnic chan-ges and lesser volume of using propofol. Key words: Propofal; Fentanyl; Mechanical ventilation; Aged patients; Hemodynamics