Observation on the sedation effects of propofol,midazolam and fentanyl in postoperative ICU patients with mechanical ventilation

Objective To study the sedation effects of propofol,midazolam and fentanyl in postoperative ICU patients with mechanical ventilation.Methods 40 postoperative ICU patients were randomly divided into group B(propofol group)and group M(midazolam group),group B were sedated to keep target depth of sedation(Ramsay score 2～5points)with infusion speed of 0.5～2mg/(kg·h),group M were sedated to keep same target depth of sedation with infusion speed of 0.05～ 0.1mg/(kg·h),and the two groups were both given fentanyl with infusion speed of 0.5μg/(kg·h).Then the Ramsay score,TSS score,Prince-Henry score,heart rate,non-traumatic mean arterial blood pressure,pulse oxygen saturation,total sedation time,recovery time after drug withdrawal,amount of fentanyl and adverse reactions of two groups were recorded.Results There were no significant differences in total sedation time,amount of fentanyl and incidence of adverse reactions between the two groups.The recovery time after drug withdrawal in group B was shorter than that in group M,and there was a significant differences(P0.05).The MBP,HR,SpO2 of two groups before sputum aspiration at pre-administration(T1),in operation(T2)and after operation at 5 min(T3) had no significant differences,but the results of intraclass had significant differences(P0.05).Conclusion The propofol,midazolam and fentanyl can provide safe and effective sedation and analgesia for postoperative ICU patients with mechanical ventilation.