Effects of Jianwei Yuyang Granule on quality of life of patients with helicobacter pylori-positive peptic ulcer

AIM: To investigate Jianwei Yuyang Granule(Radix Bupleuri,Radix codonopsis,Radix paeoniae alba,Rhizoma corydalis,etc.) the effects of on curative effect and quality of life of Helicobacter pylori(Hp)-positive peptic ulcer(PU) patients. METHODS: 46 Hp-positive PU patients whose differentiation of symptoms and signs of the traditional Chinese medicine was the stagnation of liver-QI with deficiency of the spleen type were divided randomly into Jianwei Yuyang Granule group and western medicine control group(Metronidazole,amoxycillin and ondansetron).Eradicative rate of Hp、curative effect under gastroscope、clinical curative effect in Chinese medicine syndrome were observed and quality of life were evaluated by McMaster questionnaire. RESULTS: Compared with western medicine control group,Hp eradicative rates was lower(P0.05),no difference in curative effect under gastroscope and one-year relapse rate(P0.05),Jianwei Yuyang Granule gained an advantage against western medicine with regard to effect on traditional Chinese medicine syndrome and quality of life(P0.05). CONCLUSION: Jianwei Yuyang Granule could promote ulcer healing and improved quality of life of patients with Hp positive PU and syndrome of stagnation of liver-QI with deficiency of the spleen.