Intervention by Jianwei Yuyang Pill in peptic ulcer and decrease in recurrence

AIM: To observe the influences of Jianwei Yuyang Pills(Radix pseudostellariae,Pericarpium citri reticulatae,Rhizoma dioscoreae, Fructus hordei germinatus,and Fructus crataegi) on the recurrence of peptic ulcer(PU),and the expressions of IL-1 and analyze its potential mechanism. METHODS: Thirty-six patients with gastric ulcer were chosen as Jianwei Yuyang Pills treatment group.In addition,the normal control group was set up(12 cases).The biospy specimens of gastric mucosa was detected to observe the change in immunohischemistry of IL-1 and in the contents of ninohexose and phosphatide of ulcerated gastric mucosa. RESULTS: The contents of ninohexose,phosphatide of PU patients increased in Jianwei Yuyang Pills group.There was a statistical significance between Jianwei Yuyang Pills group(before treatment) and Jianwei Yuyang Pills group(after treatment)(P0.01). There was a linear correlation between the contents of phosphatide,aninohexose and the expression of IL-1 in PU patients(P0.01). CONCLUSION: Jianwei Yuyang Pills can prevent the occurrence and relapse of ulcer and affect the hydrophobicity of gastic mucosa and strengthen the stability of myxogellayer byelevating the express of IL-1 and effecting the contents of phosphatide and aninohexose,this is maybe one of the mechanisms of Jianwei Yuyang Pills to heal ulcer quickly.