Distribution and drug resistance of pathogenic bacteria isolated from blood samples of pediatric patients in Hengyang

OBJECTIVE To investigate the distribution of pathogenic bacteria detected from the children′s blood culture and to observe the drug resistance of common pathogenic bacteria during the last three years in our hospital.METHODS 3522 children′s blood samples were cultured and detected by the BACTEC 9120,and the API half-automicroscan system was used to identify the pathogenic bacteria and their drug resistance.RESULTS Totally 212 pathogenic bacteria were isolated.The positive rate was 6.02%.Gram-positive bacteria remained the more frequent pathogens than Gram-negative bacteria.The most common organism causing bloodstream infections was coagulase-negative Staphylococcus(49.5% of the isolates),Salmonella,Escherichia,Enterococcus and Klebsiella were next in order among the isolates,accounting for 10.8%,8.0%,7.6% and 6.6%,respectively.The dominant Gram-positive pathogenic bacteria were sensitive to vancomycin.Staphylococcus was resistant against various antibiotics obviously and the resistance rate of Staphylococcus to oxacillin,penicillin,erythromycin and gentamicin was over 75.0%.Enterococcus was resistant against most antibiotics obviously,and the resistance rate of Enterococcus to penicillin and levofloxacin was 100.0%.And the resistance rate of Streptococcus to clindamycin and erythromycin was 100.0%.The dominant Gram-negative pathogenic bacteria were resistant to Cefuroxime and cephalothin.and the dominant Gram-negative pathogenic bacteria were sensitive to imipenem,meropenem,netilmicin,ceftazidime,amoxicillin/clavulanic acid and piperacillin/tazobactam.CONCLUSIONS Gram-positive bacteria are the predominant pathogents of children′s patients with septicemia and CNS ranks first on the list.Drug resistance of isolated pathogenic bacteria is a serious problem.Monitoring the change of pathogen and the trends of antimicrobial are very important in guiding the clinical administration of drugs.