Analysis of the Distribution and Antibiotic Resistance of Common Pathogenic Bacteria in Hospital

Objective To investigate the distribution of common pathogenic bacteria during the past nine years,and to observe the antibiotic resistance of common pathogenic bacteria in the last year in our hospital. Methods The API half-automicroscan system was used to identify the pathogenic bacteria and conduct antibiotic susceptibility test.Results A total of 3723 pathogenic bacteria were isolated from 13942 clinical samples.The positive rate was 26.7%.Pathogenic bacteria were distributed in 38 genera and 107 species.Gram-negative bacteria remained the more frequent pathogens than Gram-positive bacteria.Coagulase negative Staphylococcus(CNS)(15.7% of the isolates) was the most frequently isolated pathogen,followed by Staphylococcus aureus,Escherichia coli,Pseudomonas spp and Acinetobacter spp.Staphylococcus spp were sensitive to vancomycin,quinupristin / dalfopristin,nitrofurantoin,minocycline,fusidic acid,teicoplanin and rifampin.The resistance rate of Staphylococcus spp to penicillin,oxacillin and erythromycin was more than 80%.Enterococcus and Streptococcus were resistant against various antibiotics obviously,and the resistance rate of them to erythromycin and clindamycin were more than 88%.Enterococcus and Streptococcus were especially sensitive to vancomycin.The dominant Gram-negative pathogenic bacteria(except Salmonella spp) were sensitive to imipenem,meropenem and amikacin.The drug resistance rate of dominant Gram-negative pathogenic bacteria to gentamicin,cephalothin and cefuroxime were more than 60%.Salmonella spp was sensitive to various antibiotics.Conclusions The Gram-negative bacteria plays a dominant role in clinical pathogens.Except Salmonella,drug resistance of isolated pathogenic bacteria is a serious problem.Monitoring the trends of pathogenic bacteria's distribution and drug resistance will be very important in guiding the clinical administration of drugs.