Clinical analysis of topiramate in monotherapy and adjunctive therapy for post stroke partial seizure

Objective To observe the efficacy and adverse reaction of topiramate (TPM) for post stroke partial seizure in monotherapy and adjunctive therapy .Methods 24 patients with post stroke partial seizure in group A received TPM as adjunctive antiepileptic drugs (AEDs).22 patients in group B received TPM as monotherapy AEDs. The starting dose of TPM was 25 mg/d and the dose was increased weekly by 25 mg until 200 mg/d was reached, with a treatment course of 12 weeks. During the treatment course the onset of seizure and adverse reaction were recorded.Results The total effective rate and control rate in group A were 70.8% and 20.8%,which were 81.8% and 27.2% in group B respectively. There was a significant difference between the two groups (P0.05).The efficacy of TPM on the three kinds of partial seizures had no significant difference (P0.05).Main side effects in group A and B were weight decrease, somnolence, nausea and speech disorder, but the side effects of adjunctive therapy were more than those of monotherapy. There was a significant difference between the two groups (P0.01).Conclusion TPM is effective in treating post stroke partial seizure not only in adjunctive therapy but also in monotheraphy. The main side effects are weight decrease,somnolence, nausea and speech disorder. The side effects of adjunctive therapy are more than those of monotherapy.