Clinical efficacy of topiramate monotherapy in treatmnt of intractable epilepsy

Objective To assess the efficacy and safety of Topiramate (TPM)monotherapy in patients with intractable epilepsy(IE).Methods 32 patients were given TPM monotherapy(25mg once a day),the targeted dosage was 100mg TPM.There were 3 periods to reach the goal dosage:the baseline period(4weeks) to observe the seizure rate;the increase period(4~8 weeks) to increase dose to the goal dosage;the dose maintain period was 12 weeks. 30 patients were given TPM combined with other antiepileptics as control.Results In the active group 65.6% patients became seizure-free and the significaant effective rate was 78.1% with the incidence of side effect being 50%,most of which were mild and transient.In the control group the above three indexes were 13.3%,20.0%and 83.3%respectively.There was significant difference between the two groups( P 0.05).Conclusion TPM is an effective and safe agent for treatment of epilepsy.