Protective effects of Capillary artemisia polysaccharide on hepatic injury induced by obstructive jaundice in immature rats

Objective To investigate the protective effects of Capillary artemisia polysaccharide on hepatic injury induced by obstructive jaundice in immature rats.Methods Eighty immature Wistar rats were randomly divided into four groups,sham-operation group,obstructive jaundice model group,high-dose(0.8mg/kg) and low-dose(0.4mg/kg)polysaccharide intervention groups.Except for the sham-operation group,the obstructive jaundice models were made by double-ligating choledochus in the other three groups,and the rats were administered respectively.The levels of serum ALT,AST,TBIL,IBIL,DBIL and the levels of MDA,GSH,SOD in hepatic tissue homogenate were detected at 1 week and 2 weeks after the operation for the four groups.Results The activities of ALT,AST and the contents of TBIL,IBIL,DBIL in high-dose and low-dose polysaccharide intervention groups at 1 week and 2 weeks after the operation were significantly decreased,and the content of MDA in hepatic tissue homogenate was obviously reduced,however,the levels of GSH and activity of SOD were significantly increased,and there were significant differences in these indexes between the intervention groups and obstructive jaundice model group(P0.05).Conclusion Capillary artemisia polysaccharide has certain protective effects on hepatic injury induced by obstructive jaundice in immature rats.