Protective effects of Artemisia capillaries polysaccharides for hepatic fibrosis on immature rats with obstructive jaundice

Objective To investigate the protect effects of Artemisia capillaries polysaccharides for hepatic fibrosis on immature rats with obstructive jaundice.Methods Forty rats immature were divided into four groups,control group,model group [0.4 mg/(kg·d)],Artemisia capillaries polysaccharides high-dose group [0.8 mg/(kg·d)] and Artemisia capillaries polysaccharides low-dose group,obstructive jaundice were made in immature rats by double-ligating bile duct in the model group,high-dose group and low-dose group,rats in high-dose group and low-dose group were interfered with Artemisia capillaries polysaccharides 0.8 mg/(kg·d) dose were taken in high-dose group and and 0.4 mg/(kg·d) dose were taken in low-dose group with intragastric administration,physiological saline were taken in control group and model group,at two weeks after operations,the levels of serum ALT,AST,TBIL,IBIL,DBIL and the level of LA,HA,PC-Ⅲ and Ⅳ-C in serum were detected.The change of liver texture were observed with HE stain.Results At 2 weeks after operations,levels of ALT,AST,TBIL,IBIL,DBIL in serum were lower in high-dose and low-dose groups than in model group,and was higher than in control group(P 0.05),the level of LA,HA,PC-Ⅲ and Ⅳ-C was lower in high-dose and low-dose groups than in model group,and was higher than in control group(P 0.05),texture of hepatic lobule were damaged,fibroplasia was apparente in model group.The damage of hepatic lobule and fibroplasia was lighter in high-dose and low-dose groups than in model group.Conclusion Artemisia capillaries polysaccharides can decrease hepatic injury on immature rats with obstructive jaundice and lessen hepatic fibrosis.