Distribution of Pseudomonas aeruginosa infections and analysis of drug resistance

OBJECTIVE To investigate the clinical distribution and the drug resistance of Pseudomonas aeruginosa infection in order to provide basis for clinical anti-infections treatment.METHODS The specimens were collected from clinical patients with infections from Jan 2008 to Dec 2010,P.aeruginosa were isolated and the drug susceptibility was tested.RESULTS A total of 286 strains P.aeruginosa isolates were isolated from various specimens.Most of P.aeruginosa were cultured from sputum(67.8%) and wound secretion(19.6%);the infections most frequently occurred in ICU(32.2%) and department of respiratory medicine(23.4%);the result of drug susceptibility testing showed that the drug susceptibility rates of PAE to amikacin,tobramycin,cefoperazone/sulbactam,piperacillin/tazobactam,and imipenem were relatively high with the drug resistance rates less than 30.0%;the resistance rates to cefotaxime,sulfamethoxazole/trimethoprim,gentamicin,and aztreonam were higher than 50.0%.CONCLUSION Rational use of antibiotics is important for the reduction of bacterial resistance.