Therapeutic Effect of Budesonide and Formoterol Fumarate Powder for Inhalation in Children with Bronchial Asthma

Objective To explore the efficacy,tolerability and safety of Budesonide and Formoterdol fumarate powder for inhalation in treatment of children with bronchial asthma.Methods In randomized,open,parallel-group trial,44 cases of asthma were divided into group A and group B.All patients in group A inspired Budesonide Formoterol sing inspirator[80 μg(Budesonide)/4.5 μg (Formoterol)/snuff]2 times/d,12 weeks.All patients in group B inspired Budesonide(100 μg/snuff) and Formoterol(4.5 μg/snuff),1 snuff/time,respectively,2 times/d,12 weeks.Clinical symptom,visual analog scale (VAS),lung function as peak expiratory(PEF ) and forced expiratory volume in one second(FEV1),adverse-events were investigated.Results Improvement in asthma symptoms were found in the 2 groups.Improvement in the group A was earlier than that in group B(Z=-2.223,-2.042 Pa0.05) after treatment for 8,12 weeks,VAS was lower in group A than that in group B(Z=-3.877,-3.536 Pa0.05) after treatment for 8,12 weeks.Both groups got improvement in PEF predictive volue %.Improvement in group A was earlier than that in group B after 4 weeks(Z=-2.602 P0.05).Both groups got improvement in FEV1 predictive volue %.After 12 weeks,the symptoms made rapid improvement in group A compared to group B(Z=-1.966 P0.05).No adverse-events were observed in both groups.Conclusions Budesonide and Formoterol fumarate powder for inhalation and Budesonide fumarate powder for inhalation plus Formoterol fumarate powder for inhalation have good efficacy and safety.But Budesonide and Formoterol fumarate powder for inhalation provide more rapid improvement and more convenience when compared to control treatment.