Therapeutic Effect and Safety of Budesonide and Formoterol Fumarate Powder for Inhalation and Budesonide Powder for Inhalation Plus Formoterolfumarate Powder for Inhalation in Treatment of Children with Asthma

Objective To observe the therapeutic effect and safety of budesonide and formoterol fumarate powder for inhalation and budesonide powder for inhalation plus formoterol fumarate powder for inhalation in the treatment of children with asthma.Methods An open,randomized and control study was carried out in the 80 children with moderate asthma.All the children were randomly divided into treatment group and control group.Budesonide and formoterol fumarate powder for inhalation was given to children in the treatment group for 12 months,while budesonide powder for inhalation plus formoterol fumarate powder for inhalation was given to children in the control group for 12 months.All the children were regularly followed up before the treatment and 1 month,3 months,6 months,9 months,12 months after the treatment,respectively.Their parents were asked to observe and record asthmatic diary,including the frequencies of cough during day and night.Day-and-night time coughs were scored on the basis of the diaries.The peak expiratory flow(PEF) was measured at the same time.The scores of asthma control test(C-ACT)was done once every month and any adverse events were observed.SPSS 12.0 software was used to analyze the data.Results Compared with those before the treatment,the day-and-night cough scores,PEF values and C-ACT scores in 1 month,3 months,6 months,9 months and 12 months after the treatment in both control group and treatment group were significantly improved,and the diffe-rences were significant(Pa0.05).The day-and-night cough scores and PEF values in the treatment group were significantly lower than those in the control group(Pa0.05),but C-ACT scores had no significant differences between the 2 groups(Pa0.05).No adverse reaction was observed in both groups.Conclusions Both budesonide and formoterol fumarate powder for inhalation and budesonide powder for inhalation plus formterol fumarate powder for inhalation have good efficacy and safety in the treatment of children with asthma,but budesonide and formoterol fumarate powder for inhalation has better effects than budesonide powder for inhalation plus formoterol fumarate powder for inhalation.