2007•Chinese Journal of Hospital PharmacyRequires access
The research on the proective effect of Ginkgo biloba extraction on cerebral ischemia-reinfusion rats
Liao Biao-wu
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Abstract
OBJECTIVE To study the proective effect of Ginkgo biloba extraction on cerebral ischemia-reinfusion rats.METHODS 24 wistar rats were divided randomly 3 groups(sham operated group,model group and GBE Group).The activities of superoxide dismutase(SOD),the content of malondialdehyde(MDA)in cerebra and blood rheology were checked.RESULTS Compared to sham operated group,MDA and blood rheology in model group were decreased and SOD were increased(P0.01)but no change in GBE group(P0.05)except blood rheology.Compared to model group,MDA and blood rheology in GBE group were decreased and SOD were increased(P0.01 or P0.05).CONCLUSION GBE could significantly decrease the content of MDA and markedly increase the activity of SOD.It has a significant protective effect on cerebral ischemia reperfusion injury in rats.