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2012•Inner Mongolia Medical JournalRequires access

Inhibitory Effects of Ginkgo Biloba Extract on ICAM-1 Expression of Rats with Acute Lung Injury

Yang Yu-jie

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Abstract

Objective:To investigate the protective effect of ginkgo biloba extract(GBE) on lung tissues during acute lung injury(ALI) in rats and its possible mechanism.Methods:all rats were randomly divided into four groups: Control group,Lipopolysaccharide(LPS)group,dexamethasone(DEX) and GBE treatment group.Superoxide dismutase(SOD) activity and malonaldehyde(MDA) content of lung tissues were detected at 4、8 and 16 h after tail intravenous in each groups.In addition,the expression of ICAM-1 was observed via immunohistochemistry staining in lung tissues.Results:Compared with Control group,SOD activity decreased significantly in LPS group(P0.01),but MDA content and the expression of ICAM-1 increased obviously(P0.01);the administration of GBE or DEX mitigated above changes significantly(P0.05).Conclusion:GBE possessed protective effect on lung tissues during ALI through scavenging free radicals and inhibiting the expression of ICAM-1.

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What this paper is about

Objective:To investigate the protective effect of ginkgo biloba extract(GBE) on lung tissues during acute lung injury(ALI) in rats and its possible mechanism.Methods:all rats were randomly divided into four groups: Control group,Lipopolysaccharide(LPS)group,dexamethasone(DEX) and GBE treatment group.Superoxide dismutase(SOD) activity and malonaldehyde(MDA) content of lung tissues were detected at 4、8 and 16 h after tail intravenous in each groups.In addition,the expression of ICAM-1 was observed via immunohistochemistry staining in lung tissues.Results:Compared with Control group,SOD activity decreased significantly in LPS group(P0.01),but MDA content and the expression of ICAM-1 increased obviously(P0.01);the administration of GBE or DEX mitigated above changes significantly(P0.05).Conclusion:GBE possessed protective effect on lung tissues during ALI through scavenging free radicals and inhibiting the expression of ICAM-1.

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Available abstract

Objective:To investigate the protective effect of ginkgo biloba extract(GBE) on lung tissues during acute lung injury(ALI) in rats and its possible mechanism.Methods:all rats were randomly divided into four groups: Control group,Lipopolysaccharide(LPS)group,dexamethasone(DEX) and GBE treatment group.Superoxide dismutase(SOD) activity and malonaldehyde(MDA) content of lung tissues were detected at 4、8 and 16 h after tail intravenous in each groups.In addition,the expression of ICAM-1 was observed via immunohistochemistry staining in lung tissues.Results:Compared with Control group,SOD activity decreased significantly in LPS group(P0.01),but MDA content and the expression of ICAM-1 increased obviously(P0.01);the administration of GBE or DEX mitigated above changes significantly(P0.05).Conclusion:GBE possessed protective effect on lung tissues during ALI through scavenging free radicals and inhibiting the expression of ICAM-1.

Key concepts: Ginkgo biloba, Medicine, Dexamethasone, Superoxide dismutase, Lung, Lipopolysaccharide, Ginkgo, ICAM-1

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