Prospective study on Atorvastatin for prevention relapsed acute cerebral infarction in high-risk patient

Objective:To explore the clinical pharmacological effects of atorvastatin on preventing relapsed cerebral infarction in high-risk patient,and to investigate the influence of atorvastatin on the inflammatory factors,serum lipids and carotid artery atherosclerosis in patients with cerebral infarction.Methods:A total of 156 patients with the first onset of acute cerebral infarction were divided into control group(n=66) and observation group(n=90).The control group was given conventional therapy,observation group take atorvastatin 20 mg/d,both for 6 months.Serum lipids and inflammatory factors,the carotid artery intimal and media thickness(IMT) and plaque areas were measured before and 6 months after treatment.Results:The improvement in serum lipids,carotid artery atherosclerosis,IMT and carotid artery plaque area in observation group were better than those in the control group(P0.05 or 0.01).The six-month recurrence rate of observation group was significantly lower than that of the control group(5.56% vs.21.2%,P0.01).Conclusion:Atorvastatin calcium can significantly improve endothelial function,lipid levels and carotid atherosclerotic plaque stability in patients with acute cerebral infarction,and promote plaque regression,reduced the recurrence rate of cerebral infarction.