2010•Xinxueguan kangfu yixue zazhiRequires access
Therapeutic role of atorvastatin in hypertensive patients with carotid atherosclerosis
Zhang An-xing
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Abstract
Objective:To investigating the therapeutic role of atorvastatin in hypertensive patients with carotid atherosclerosis. Methods:A total of 182 patients with hypertension of stage 2 and carotid atherosclerosis were average randomly divided into two groups: atorvastatin group (n=91) and routine therapy control group (control group,n=91) and were all given standard treatment of hypertension, but atorvastatin group was given atorvastatin tablets also. The incidence of brain infarction during different period of treatment was observed. Results: Incidence of brain infarction in 3 months of atorvastatin treatment group showed no significant difference with that of control group(1.1% vs. 2.2%, P0.05), but the incidence in two years was significantly lower than that of control group (2.2% vs. 9.9%, P0.05). Conclusion: Atorvastatin can improve the stabilization of atherosclerotic plaque and endothelial function. So it plays an active role in improving the long term prognosis in patients with brain infarction.