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Clinical Observation on Combination Chemotherapy with HCPT Low Dose DDP and 5-FU Continuous Infusion in the Treatment of Advanced Gastric Cancer

Zhu Ya

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Abstract

Objective To evaluate the efficacy and toxicity of HCPT,low dose DDP and 5_FU continuous infusion for treatment of advanced gastric cancer.Methods A total of 36 patients were enrolled in the trial.HCPT 10 mg by intravenous titration d1～5,DDP 6mg/(m 2·d) by intravenous titration during the first day to the fifth day every week,5_Fu 0.25/(m 2·d) every day by continuous infusion for 3 weeks,every 31 days,Each patient was given at least 2 cycles.Results A complete response was observed in 2 cases and a partial response in 16 cases,and overall response rate of 50.0%.Toxic effects included nausea,leukopenia and vomiting,Main side effects were grade Ⅰ～Ⅱ.Conclusion This study confirmed that combination chemotherapy with HCPT,low dose DDP and 5_Fu continuous infusion is a safe and effective regimen for patients with advanced gastric cancer and is worthy of further clinical trial.

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What this paper is about

Objective To evaluate the efficacy and toxicity of HCPT,low dose DDP and 5_FU continuous infusion for treatment of advanced gastric cancer.Methods A total of 36 patients were enrolled in the trial.HCPT 10 mg by intravenous titration d1～5,DDP 6mg/(m 2·d) by intravenous titration during the first day to the fifth day every week,5_Fu 0.25/(m 2·d) every day by continuous infusion for 3 weeks,every 31 days,Each patient was given at least 2 cycles.Results A complete response was observed in 2 cases and a partial response in 16 cases,and overall response rate of 50.0%.Toxic effects included nausea,leukopenia and vomiting,Main side effects were grade Ⅰ～Ⅱ.Conclusion This study confirmed that combination chemotherapy with HCPT,low dose DDP and 5_Fu continuous infusion is a safe and effective regimen for patients with advanced gastric cancer and is worthy of further clinical trial.

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Available abstract

Objective To evaluate the efficacy and toxicity of HCPT,low dose DDP and 5_FU continuous infusion for treatment of advanced gastric cancer.Methods A total of 36 patients were enrolled in the trial.HCPT 10 mg by intravenous titration d1～5,DDP 6mg/(m 2·d) by intravenous titration during the first day to the fifth day every week,5_Fu 0.25/(m 2·d) every day by continuous infusion for 3 weeks,every 31 days,Each patient was given at least 2 cycles.Results A complete response was observed in 2 cases and a partial response in 16 cases,and overall response rate of 50.0%.Toxic effects included nausea,leukopenia and vomiting,Main side effects were grade Ⅰ～Ⅱ.Conclusion This study confirmed that combination chemotherapy with HCPT,low dose DDP and 5_Fu continuous infusion is a safe and effective regimen for patients with advanced gastric cancer and is worthy of further clinical trial.

Key concepts: Medicine, Nausea, Leukopenia, Vomiting, Chemotherapy, Regimen, Continuous infusion, Toxicity

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Clinical Observation on Combination Chemotherapy with HCPT Low Dose DDP and 5-FU Continuous Infusion in the Treatment of Advanced Gastric Cancer — Research Paper | ScholarLens