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Clinical Study of Continuous Infusion of 5 - Fu、CF、DDP、10 - HCPT in 39 Patients with Advanced Gastrointestinal Carcinoma

Jin Li

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Abstract

Objective To study the clinical response and toxic - side reactions of 39 patients with advanced gastrointestinal carcinoma treated with continuous infusion of fluorouracil CF,DDP,10 - HCPT.Methods A scheme of HLFP was used to treat 39 patients with gastric cancer or colorectal cancer.Regimen: 10- HCPT 6 mg/(m2·d) iv for 5 days,5 - Fu 500 mg/(m2·d) iv for 5 days by continuous infusion,DDP 30 mg/(m2·d) iv for 3 days.The scheme was repeated every 21 days.Results Of 25 cases of gastric cancer,1 achieved CR and 10 PR;the response rate was 40.0% ;of 14 colorectal cancer,5 achieved PR with response rate of 37.5% .The main toxic side effects included GI reaction,myelosuppression and alopecia.Conclusions HLFP combined chemotherapy has a better response in the treatment of gastrointestinal carcinoma.The side effects are mild. It can be used widely in clinical work.

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Objective To study the clinical response and toxic - side reactions of 39 patients with advanced gastrointestinal carcinoma treated with continuous infusion of fluorouracil CF,DDP,10 - HCPT.Methods A scheme of HLFP was used to treat 39 patients with gastric cancer or colorectal cancer.Regimen: 10- HCPT 6 mg/(m2·d) iv for 5 days,5 - Fu 500 mg/(m2·d) iv for 5 days by continuous infusion,DDP 30 mg/(m2·d) iv for 3 days.The scheme was repeated every 21 days.Results Of 25 cases of gastric cancer,1 achieved CR and 10 PR;the response rate was 40.0% ;of 14 colorectal cancer,5 achieved PR with response rate of 37.5% .The main toxic side effects included GI reaction,myelosuppression and alopecia.Conclusions HLFP combined chemotherapy has a better response in the treatment of gastrointestinal carcinoma.The side effects are mild. It can be used widely in clinical work.

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Available abstract

Objective To study the clinical response and toxic - side reactions of 39 patients with advanced gastrointestinal carcinoma treated with continuous infusion of fluorouracil CF,DDP,10 - HCPT.Methods A scheme of HLFP was used to treat 39 patients with gastric cancer or colorectal cancer.Regimen: 10- HCPT 6 mg/(m2·d) iv for 5 days,5 - Fu 500 mg/(m2·d) iv for 5 days by continuous infusion,DDP 30 mg/(m2·d) iv for 3 days.The scheme was repeated every 21 days.Results Of 25 cases of gastric cancer,1 achieved CR and 10 PR;the response rate was 40.0% ;of 14 colorectal cancer,5 achieved PR with response rate of 37.5% .The main toxic side effects included GI reaction,myelosuppression and alopecia.Conclusions HLFP combined chemotherapy has a better response in the treatment of gastrointestinal carcinoma.The side effects are mild. It can be used widely in clinical work.

Key concepts: Medicine, Fluorouracil, Gastrointestinal cancer, Gastroenterology, Regimen, Chemotherapy, Colorectal cancer, Internal medicine

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Clinical Study of Continuous Infusion of 5 - Fu、CF、DDP、10 - HCPT in 39 Patients with Advanced Gastrointestinal Carcinoma — Research Paper | ScholarLens