Effect of adenosine on the expression of adhesion molecules CD11b/CD18 in patients with coronary heart disease

Objective To explore the effect of different doses of adenosine on the expression of adhesion molecules CD11b/CD18 in neutrophils and monocytes in patients with coronary heart disease(CHD).Methods The patients(who were diagnosed by clinical symptoms,changes of electrocardiogram and myocardial biochemical markers)and normal healthy individuals were drew blood,the blood of patients was given different doses of adenosine to intervene.The expression of CD11b/CD18 in neutrophils and monocytes of normal people and patients were measured by direct immunofluorescence techniques associate with flow cytometry.Results Expression of CD11b/CD18 in neutrophils and monocytes in CHD patients were markedly higher than those in normal cases(P0.01),but expression of CD11b/CD18 in acute myocardial infarction(AMI)and unstable angina pectoris(UAP)were not significantly different(P0.05).Adenosine can reduced expression of CD11b/CD18 in neutrophils and monocytes in 10,30,100 μmol/L(P0.05),but expression of CD11b/CD18 in 30 μmol/L and 100 μmol/L were not significantly different(P0.05).Conclusion The incidence of coronary heart disease may be related with the increase of CD11b/CD18 expression.Adenosine may reduce adhesion between white blood cell and endothelial cell by reducing CD11b/CD18 expression.