The effect of adenosine to the expression of adhesion molecules CD11b/CD18 in patients with coronary heart disease

Objective:To explore the effect of the different doses AMP579 and adenosine to the expression of adhesion molecules CD11b/CD18 on neutrophils in different types of patients with coronary heart disease(CHD).Methods:The patients and normal healthy individuals were drew blood,patients blood were given different doses of adenosine and AMP579 to interval,the expression of CD11b/CD18 on neutrophils of normal people and patient were measured by direct immunofluorescence techniques associated with flow cytomerey.Results:Expression of CD11b/CD18 on neutrophils in the CHD patients were markedly higher than those in normal cases(P0.01).Adenosine can reduced expression of CD11b/CD18 in CHD patients on neutrophils in 10,30,100 μmol(P0.05),but expression of CD11b/CD18 in 30 μmol and in 100 μmol were no significantly different(P0.05).In AMP579 groups,the expression of CD11b/CD18 in CHD patients on neutrophils were no decreased significantly,there were no statistical significant(P0.05).Conclusion:The incidence of coronary heart disease related with the increasing of CD11b/CD18 expression,adenosine can reduce CD11b/CD18 expression to reduce the adhesion of white blood cell and endothelial cell.AMP579 can′t reduce the expression of CD11b/CD18 on neutrophils of CHD patients in 1,10,30 μmol.