Analysis of the distribution and drug resistance of pathogens responsible for urinary tract infections

Objective To ascertain the distribution of pathogens responsible for urinary tract infections among patients at this hospital and their drug resistance to routinely used antibiotics.Methods Urine cultures from outpatients and inpatients were statistically analyzed.Bacteria were identified,susceptibility testing was performed,and statistical analysis was done with the VITEK-60 automated microbial ID system.Results Two hundred and eighty-six strains of bacteria were isolated.Of these strains,205 were Gram-negative(71.68%) and 81 were Gram-positive(28.32%).Accounting for the top 6 strains isolated were Escherichia coli(166 strains,58.04%),Enterococcus(53 strains,18.53%),coagulase-negative Staphylococcus(15 strains,5.24%),Klebsiella pneumoniae(11 strains,3.85%),fungi accounted(10 strains,3.50%),and Neisseria gonorrhoeae(8 strains,2.80%).Of the strains,53.30% were ESBL-producing ones,70.58% were MRS,60.95% were HLAR,and 0 were VRE.E.coli was 100.0% sensitive to imipenem,followed by nitrofurantoin and piperacillin/tazobactam and cefepime.Resistance of Gram-negative bacilli to ampicillin,ampicillin/sulbactam,gentamicin,and cefazolin was greater than 60.00%.Gram-positive cocci were 100.0% sensitive to vancomycin,followed by nitrofurantoin.Resistance of Enterococcus to gentamicin,penicillin,oxacillin,and levofloxacin was greater than 77.36%.Conclusion E.coli and Enterococcus were the pathogens mainly responsible for urinary tract infections in this hospital.Pathogens had a particularly high resistance rate.Clinicians should choose suitable antibiotics based on the results of urine cultures and drug sensitivity tests.