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A COMPARATIVE STUDY ON NATURAL AGING MICE AND D-GALACTOSE AGING MICE MODE.

Hao Zhang

Abstract

Objective:To select experimental animal used in the antiaging test by comparison of natural aging mice and D-galactose aging-mice mode.Methods:The contents of Malondialdehyde(MDA) in liver and the activities of Superoxide Dismatase(SOD) in red blood cell both in natural aging-mice and D-galactose aging-mice model were measured,and comparing with young mice control group.Results:The activity of SOD in serum in D-galactose-aging mice model is significantly decreased,but the content of MDA in liver is not increased.There is a significant difference between the young mice and natural aging mice both in the activity of SOD in serum and the content of MDA in liver.Conclusion:Natural aging mice is better than the D-galactose mice model as experimental animal used in the antiaging test.

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Key concepts: Galactose, Malondialdehyde, Animal model, Superoxide dismutase, Endocrinology, Internal medicine, Experimental animal, Chemistry