RESEARCH ON CLINICAL CORRELATION BETWEEN SERUM SOLUBLE FAS,INFLAMMATORY FACTORS AND DIFFERENT TYPES OF CORONARY HEART DISEASE

Objective To evaluate the relationship between serum levels of soluble Fas(sFas),TNF-α,IL-6 and different clinical types of coronary heart disease(CHD) and the severity of coronary lesions.Methods By enzyme-linked immunosorbent assay(ELISA),serum levels of sFas,TNF-α and IL-6 were measured from 30 patients with acute myocardiac infarction(AMI),13 patients with unstable angina pectoris(UAP),14 patients with stable angina pectoris(SAP) and 23 subjects as controls.The patients with angina pectoris(AP)、the control group and some patients with AMI underwent coronary angioplasty(CAG).The gensini score of artery stenosis and the serum levels of sFas,TNF-α and IL-6 were compared with those of 23 controls respectively.Results Significant increase in the concentrations of sFas were found in the serum from patients with AMI and UAP relative to those SAP and controls(P0.01).Mean level of TNF-α was significantly higher in patients with AMI and UAP than those in controls(P0.05).The serum levels of IL-6 were increased in patients with UAP compared to the patients with SAP or controls(P0.05).The level of IL-6 in patients with AMI was also higher than that in patients with SAP and control group(P0.01).Moreover,in patients with CHD,sFas and TNF-α were positively correlated(r=0.289,P=0.029).IL-6 and TNF-α were also positively correlated in patients with CHD(r=0.271,P=0.042).Serum levels of sFas were higher in the severe and moderate groups than those in the control group(P0.01).Serum levels of sFas were higher in the moderate groups than those in the minor group(P0.05).Serum levels of TNF-α were higher in the severe and moderate groups than those in the control and minor groups(P0.05).Serum levels of IL-6 were higher in the severe and moderate groups than those in the controls(P0.01,P0.05),and these groups were also higher than that in minor group(P0.05).Double ramus group and multitude ramus group were higher than single ramus group in Gensini score.The level of sFas in single ramus group was higher than that in control group(P0.05).The levels of sFas,TNF-α and IL-6 in double ramus group were higher than those in the control group(P0.01,P0.05,P0.01).The level of TNF-α in multitude ramus group was also higher than those in control group(P0.05).Conclusion High levels of sFas,TNF-α and IL-6 were significantly correlated with CHD,especially in the occurrence of ACS.The immune reaction and inflammatory response may play an important role in the development of vulnerable atherosclerotic plaque.The interaction may exist in the development.