Changes of Plasma Interleukin-18,Interleukin-10 in Patients with Coronary Heart Disease and Its Clinical Significance

【Objective】To investigate the changes of interleukin-18(IL-18),interleukin-10(IL-10) and IL-18/IL-10 ratio in patients with coronary heart disease(CHD),and to explore their contributions in the development of CHD.【Methods】Ninety six patients with CHD were divided into three groups: group A(Gensini score26),group B(Gensini score between 26～54) and group C(Gensini score54).The concentrations of plasma IL-18 and IL-10 in patients were measured by enzyme linked immunosorbent assay(ELISA).【Results】The concentrations of plasma IL-18,IL-10 and IL-18/IL-10 ratio in the group of CHD were higher than those in the control group,The concentration of plasma IL-18 and IL-18/IL-10 ratio in the patients with acute myocardial infarction(AMI) were higher than those in the patients with unstable angina pectoris(UAP) and stable angina pectoris (SAP),and those in the patients with UAP were higher than those in the patients with SAP(P0.01).The concentration of plasma IL-10 in the patients with UAP and AMI were higher than those in patients with SAP(P0.01).The concentration of plasma IL-18 and IL-18/IL-10 ratio in group C were higher than those in group A and group B,and those in group B were higher than those in group A(P0.01).【Conclusion】The concentration of plasma IL-18 and IL-18/IL-10 ratio in the group of CHD are higher than those in the control group,and to a certain extent,they may reflect the severity of the illness and be used as reference indexes for risk stratification and severity evaluation of CHD.The imbalance of IL-18/IL-10 is probably relative to the development of CHD.