Research of Clinical Correlation between Serum Levels of TNF-α,IL-6 and Different Types of Coronary Heart Disease

Objective To evaluate the relationship between serum levels of TNF-α,IL-6 and different clinical types of coronary heart disease(CHD) and the severity of coronary lesions.Methods By using enzyme-linked immunosorbent assay(ELISA),the serum levels of TNF-α and IL-6 were measured in 30 patients with AMI,13 patients with UAP,14 patients with SAP and 23 subjects without CHD(as control).The patients with AP or AMI and patients in the control group all underwent the coronary angioplasty(CAG).Results Mean level of TNF-α was significantly higher in patients with AMI and UAP than those in control(P0.05).The serum levels of IL-6 were significantly increased in patients with UAP compared to the patients with SAP or control(P0.05).The level of IL-6 in patients with AMI were also higher than those in patients with SAP and control group(P0.01).IL-6 and TNF-α were also positively correlated in patients with CHD(r=0.271,P=0.042).Serum levels of TNF-α were higher in the severe and moderate groups than those in the control and minor groups(P0.05).Serum levels of IL-6 were higher in the severe and moderate groups than those in the control(P0.01,P0.05).Conclusion The high levels of TNF-α and IL-6 were significantly correlated with CHD,especially in the occurrence of ACS.The inflammatory response may play an important role.