Significance of the changes in serum soluble intercellular adhesion molecule-1 in patients with hepatocellular carcinoma before and after TACE

Objective To investigate the clinical significances of the changes in serum soluble intercellular adhesion molecule-1(sICAM-1)in patients with hepatocellular carcinoma(HCC)before and after transcatheter hepatic arterial chemoembolization(TACE).Methods The serum levels of sICAM-1 in 50 patients with HCC before the first TACE,on the 3rd day,7th day and 1 month after TACE and that of 50 healthy participants were respectively detected by ELISA and compared.Results Compared with control group([197.29±38.87]μg/L),the level of sICAM-1 in patients with HCC before the first TACE([651.08±65.29]μg/L)increased significantly(P0.01).Among all HCC cases,the level of sICAM-1 before TACE in the patients with portal vein tumor thrombli was significantly higher than that in the group without portal vein thrombosis(P0.01).There was no significant difference in patients with HCC among different AFP groups before the first TACE(P0.05).The level of sICAM-1 declined significantly on the 3rd day and 7th day after TACE([539.60±61.94]μg/L,[496.22±58.78]μg/L,respectively,P0.01).There was no remarkable changes for the level of sICAM-1 before and 1 month after TACE([597.32±81.60]μg/L,P0.05)Conclusion slCAM-1 levels in patients with HCC were closely related to the activity of the tumor.It can be used for the evaluation of HCC metastasis,recurrence and prognosis.Especially for those AFP are negative,dynamic changes of serum sICAM-1 is helpful to estimating the prognosis after TACE and the indication of re-TACE treatment.