Change and Significance of Soluble Intercellular Adhesion Molecule-1 in Hepatocellular Carcinoma Patients before and after Transcatheter Arterial Embolization

Objective To observe the changes of serum soluble intercellular adhesion molecule-1(slCAM-1)in patients with hepatocellular carcinoma(HCC)before and after transcatheter arterial chemoembolization(TACE)and to identify clinical significance of serum sICAM-1 in estimating the activity of the tumour.Method Serum sICAM-1 in patients with HCC were detected by ELISA before the first TACE,3 days after TACE,7 days after TACE and 1 month after TACE respectively.Results Compared with control group(201.07±68.81)μg/L,the level of serum sICAM-l in patients with HCC before the first TACE(647.94±95.69)μg/L increased significantly(P0.01).The level of serum sICAM-l had not significant difference in patients with HCC before the first TACE between different AFP groups.The level of serum sICAM-l declined remarkably 3 after TACE,7 days after TACE(567.85±99.79 μg/L,542.84±89.94 μg/L,respectively).and the level of serum sICAM-l of 7 days is lower than the level of serum sICAM-l of 3 days after TACE(P=0.0220.05).The level of serum sICAM-l had not significant difference between 1 month after TACE and before TACE in patients with HCC(P=0.1240.05).Significant difference was found in the reduction rate of sICAM-1 between the group which the iodine oil deposition is good and the group which is bad 1month after the operation.(16/18,2/10,respectively,P0.01).Conclusion It can be concluded that slCAM-1 levels in patients with liver carcinoma were closely related to the activity of the tumour.The changes of serum sICAM-1 are valuable in estimating the prognosis after TACE and evaluating the indication of re-TACE treatment in patients with HCC especially those AFP are negative.